Chelsea have been paired with Champions League holders Real Madrid in the quarter-finals, while Pep Guardiola faces a reunion with former club Bayern Munich for Manchester City.
Both Premier League sides will meet each other in the semi-final, should both Chelsea and City advance through their last-eight ties.
Meanwhile, there will be an all-Italian derby in the quarter-finals as Serie A champions AC Milan face current leaders Napoli, while Inter Milan will take on Benfica.
Champions League quarter-final draw in full:
First legs on April 11 or April 12, second legs April 18 or April 19
Real Madrid vs Chelsea
Benfica vs Inter Milan
Manchester City vs Bayern Munich
AC Milan vs Napoli